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Neurokinin B, Menopause and Hot Flushes

Hot flushes can be uncomfortable and embarrassing in equal measure. They’re a common symptom of menopause, and you may already know that they occur when the oestrogen levels in your body drop. But have you heard of neurokinin B? This hormone also plays a key role in the onset of this sometimes debilitating menopause symptom.

What Is Neurokinin B?

Neurokinin B has been identified as controlling hot flushes, which means efforts to block the hormone could possibly help to get this menopause symptom under control.

Sometimes also referred to as NKB, the hormone can activate the parts of the brain that control temperature, triggering the overheating and excess sweating that are associated with hot flushes.

So, if it’s known what specifically causes hot flushes, could targeting this hormone get them under control?

Targeting Neurokinin B

Scientists have been exploring how drugs containing a neurokinin 3 receptor (NK3R) could potentially help with managing this menopause symptom.

In an initial trial carried out in early 2018 by doctors from Imperial College London, King’s College London and a group of pharmaceutical firms, the drug - known as MLE4901 - showed promise for reducing the severity of hot flushes when compared to a placebo.

First author of the study, Dr Julia Prague of Imperial College London, explained: “As NKB has many targets of action within the brain, the potential for this drug class to really improve many of the symptoms of the menopause, such as hot flushes, difficulty sleeping, weight gain and poor concentration, is huge.”

This could therefore provide hope to women who find this menopause symptom debilitating and are looking for an alternative to HRT (hormone replacement therapy).

However, the results are only from a small study cohort, which means that further, larger-scale trials would be needed before the drug could potentially come to market.

Dr Prague added that the findings suggest “great promise for the future of this new type of treatment”.

In the meantime, women all over the world will still be experiencing hot flushes caused by the change in their hormonal balance that typically occurs in their early 50s, so what else can be done to manage this uncomfortable menopause symptom?

Get Hot Flushes Under Control

Declining oestrogen levels are responsible for triggering the onset of menopause symptoms, which can send both physical and psychological functions haywire. Therefore, finding a way to rebalance the hormones could help with getting symptoms such as hot flushes under control.

Also offering an alternative to HRT, Femarelle® menopause supplements contain DT56a, which is naturally derived from soy, and can mimic the effects of oestrogen in the body. As a result, it can potentially provide relief from hot flushes and other menopause symptoms, helping you to continue feeling comfortable, confident and empowered at every stage of your life.

Femarelle® Recharge is specifically designed to help you with managing symptoms in your 50s, but if you need support with hot flushes earlier or later than this, Femarelle® Rejuvenate and Femarelle® Unstoppable are also available.

There are other steps you can take to try to get hot flushes under control naturally too, such as avoiding alcohol, caffeine and overly spicy food, and wearing breathable, easily removable layers to keep yourself as cool as possible.

Shop the full Femarelle® collection from Menopause Supplements here.